Engineering Agrobacterium for the 21st century
BasidioBio uses synthetic biology to engineer user-defined control over Agrobacterium-mediated transformation in plants and fungi.
One transformation, numerous uncontrollable outcomes
The Challenge
Transformation runs on 1990s tools
- The field still relies on Agrobacterium strains and binary vectors designed in the 1990s
- Users lack control over transgene insertion number, integrity, efficiency, and stability
The Solution
Multiplexed screening across diverse determinants of transformation outcome
- Screen thousands of candidates in weeks—not single variants over months
- Optimize across efficiency and quality metrics for user-defined transformation outcomes
Transgenic Crop Biotechnology
Applications
Unique solutions for specific engineering goals
Plant Gene Editing
Plant Molecular Pharming
Fungal Biotechnology
Team
The people behind BasidioBio
Matthew Szarzanowicz, PhD
CEO & Co-founder
- Pioneer in Agrobacterium and binary vector engineering
Mitchell Thompson, PhD
Scientific Advisor & Co-founder
- Leader in microbial synthetic biology and Agrobacterium Ti plasmid refactoring
Patrick Shih, PhD
Scientific Advisor & Co-founder
- World leader in plant synthetic biology
Larry Gilbertson, PhD
Scientific Advisor
- Plant biotechnology expert with 20+ years of industry experience across Monsanto and Bayer
Key Publications & Patents
Binary vector copy number engineering improves Agrobacterium-mediated transformation
Szarzanowicz et al., 2024. Nature Biotechnology
PCT/US2025/032788
Quantitative dissection of Agrobacterium T-DNA expression in single plant cells reveals density-dependent synergy and antagonism
Alamos et al., 2025. Nature Plants
PCT/US2025/026509
Supported by
Let's talk
Whether you're exploring a partnership, curious about the technology, or just want to learn more — reach out directly.
mszarz@basidio.bio© 2026 BasidioBio, Inc.